Depends on what you're using it for. If you want to do family type gravel path rides on pretty flat terrain where you spend lots of time seated then yeah, don't go crazy on the sta.
I went from an M/L stylus to an L rootdown so from 75 STA and 458 reach to 76sta and 478 reach.
The stylus was definitely more comfortable when just pedalling along a fairly flat road, but nowhere near as capable or comfortable in any other situation. No quarter climb or good sir Martin type of situation I prefer the steeper STA. Or that steep little climb on sticks and stones right after you ride around the big rocks, or the armored climb at the northwest end of salamander, stuff like that is way easier to punch up. The last two examples require a bit of standing pedalling but I find transitioning in and out of the saddle goes more smoothly.
A stylus or wide-angle set up with the stack fairly high and the seat slid back would be totally fine pretty much anywhere in terms of avoiding wrist pain.