I would imagine it would be quite a bitch to maneuver the wheel around to get the tire off and stuff while it was still attached to the bike. I've never tried it, and it's possible, but I bet it's easier when you have the wheel free and in your lap.
Question: what do you do if you toast the front wheel on it? What if the hub needs rebuilding? Or are you talking about bolt on vs QR?
well obviously you don't nedd to take off the front wheel to change a tire
if you toast the front wheel you build another one just like any other bike ,the manufacturer is on the same continent as you , parts/bikes /whatever comes by ups in however long that takes from eastern U.S.
from a tech perspective the cannondale dealer has a special axle to put the wheel into a park truing stand