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I'm no expert in the mix/match that's possible with modern drivetrains - we have Andrew for that.
Assuming that shifter/RD combo works in the mtb realm, I'd bet it doesn't work here as the GRX pull ratio will be different, no? You could likely utilize the cassette, but you'd need to run it with a RoadLink or Garbaruk cage.
The Deore cassette is **2/3rds** of a pound heavier, although I realize that's not a factor for many folks. I'd probably spend the extra hundred bucks for the Garbaruk?
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